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A process for obtaining an antibody-drug conjugate according to any one of claims 1-23, wherein the method comprises: culturing a host cell under conditions suitable for production of an anti-FRa antibody as defined in any one of embodiments 1-21 , isolating said anti-FRa antibody, synthesis of exatecan bonded to the linker L of formula (VIII): EXAMPLES Functional Assays Human FRa-binding affinity by ELISA Sandwich ELISA assays are performed using 96-well high-binding ELISA plates (Corning Inc., New York, NY, USA, Cat#3590)

A failure to maintain epigenetic homeostasis in the immune response due to factors including environmental influences leads to aberrant gene expression, contributing to immune dysfunction and, in some cases, the development of autoimmunity in genetically predisposed individuals

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New ophiobolin derivatives from the marine fungus aspergillus flocculosus and their cytotoxicities against cancer cells