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Match the tool to the pathway you're testing, verify purity with every batch, and design your controls around the specific mechanism you've selected

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Urs NM, Peterson SM, Caron MG (2017) New concepts in dopamine D2 receptor biased signaling and implications for schizophrenia therapy

J Immunol 193(5):24272437 Lyle LT et al (2016) Alterations in pericyte subpopulations are associated with elevated Blood-Tumor barrier permeability in experimental brain metastasis of breast cancer