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This upregulation exacerbates corneal injury by triggering an inflammatory response and driving the growth of new blood vessels, resulting in significant corneal damage through neovascularization (155, 156)

This can lead to effects on bone mineral density, muscle mass, and metabolism, though specific responses vary among subjects

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Proteomics and metabolomics in varicocele-associated male infertility: advancing precision diagnostics and therapy

Proc Natl Acad Sci USA 113:E4966E4975 Yang WS, SriRamaratnam R, Welsch ME, Shimada K, Skouta R, Viswanathan VS, Cheah JH, Clemons PA, Shamji AF, Clish CB et al (2014) Regulation of ferroptotic cancer cell death by GPX4