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Nontargeted elucidation of metabolic pathways using stable-isotope tracers and mass spectrometry

The liver , as a primary source of iron storage, is particularly susceptible to iron overload and related damage, which may range from enlargement (hepatomegaly) and elevated serum liver enzymes, to fibrosis or cirrhosis (Siddique 2012)

24,25 Upon activation, TAK1 activates the downstream kinase IKK, which in turn phosphorylate the NF-B inhibitor IB, leading to ubiquitin-dependent IB degradation and NF-B activation