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Recent studies suggest that BAs also play important roles in the adaptive immune response and modulate the secretion of IL-12 in DCs, inhibiting the differentiation of Th17 cells but promoting that of Treg cells [9,10]

In addition to small molecules, proteins that regulate the mitochondrial stress response also contribute to redox homeostasis

Insulin secretion was only affected by somatostatin at 12 mmol/l glucose, demonstrating that a tonic inhibition by endogenous somatostatin does not contribute to the very low levels of insulin at low glucose levels, whereas a paracrine inhibitory effect by local somatostatin plays a significant role in the regulation of insulin secretion at higher glucose levels

Macarulla, T