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Reports were further limited to those with an event date from 1 st January 2012 through to 31 st of December 2018 and where the patient was 45 years or older as there is low incidence of COPD before 45 years of age and low likehood of patients developing symptoms of COPD before 45 years of age [46, 47]

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PubMed, doi:10.1002/ajmg.b.32281