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Direct hepatotoxicity (inherent DILI) is the direct damage caused by drugs and their metabolites to liver cells or mitochondria

Cell 148(6):12041222 Huang Y, Liu XQ, Wyss-Coray T, Brecht WJ, Sanan DA, Mahley RW (2001) Apolipoprotein E fragments present in Alzheimers disease brains induce neurofibrillary tangle-like intracellular inclusions in neurons