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In populations who cannot exercise due to frailty, physical disability, or cardiovascular limitations, MOTS-c represents one of the most compelling candidates in the emerging class of pharmacological exercise mimetics

The unfolded protein response (UPR) is triggered when an excessive amount of misfolded proteins accumulate in the ER, which can be caused by overnutrition, increased reactive oxygen species (ROS), or proinflammatory cytokines ( Figure 2A )

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