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Gynecomastiaas observed in androgen-insensitivity syndromeis absent in 5-reductase-2-deficient males

They are problems with how the molecule is asked to perform a job it cannot do under topical-only conditions

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Kikuchi, M., Itoh, S., Ichinose, S., Shinomiya, K

(39), the Bliss synergy score was defined as follows for reduced drug combinations: According to the Bliss criterion, when two independent drugs are combined, their effects simply add up, and the Bliss synergy score is zero