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The study was approved by the Ethics Committee of Thomayer Hospital and the Institute of Clinical and Experimental Medicine, Prague, Czech Republic and carried out in accordance with the approved guidelines

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263 PihlajaR.TakkinenJ.EskolaO.VasaraJ.Lpez-PicnF

hMLH1 expression and cellular responses of ovarian tumour cells to treatment with cytotoxic anticancer agents

When, however, the level of ROS overwhelms these cellular defenses, the cell will sustain damage (in a dose-dependent manner) that can lead to carcinogenesis, teratogenesis, necrosis, or apoptosis (Fig