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Editor information Editors and Affiliations Rights and permissions Copyright information 2023 The Author(s), under exclusive license to Springer Nature Switzerland AG About this chapter Cite this chapter Rooney, S., Hudson, V., Gourgiotis, S

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The ability of SASP secreted by senescent cells to induce CD38 NADase activity and NAD + consumption in neighboring cells thus establishes a niche-specific paracrine network linking cellular senescence and NAD + decline 27

Applications and clinical trial landscape using Toll-like receptor agonists to reduce the toll of cancer