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In vitro , these non-replicating dormant bacilli can be obtained and studied by setting up the hypoxia-induced dormancy Wayne model ( In order to study the expression of MetE during the different stages of Mtb, from aerobic, actively replicating to anaerobic, non-replicating bacilli, we investigated the presence of MetE protein in the supernatants of dormant Mtb cultures (H) and compared them with those of actively replicating cultures (A)

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