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In another embodiment, monocytes and/or macrophages having a reduced inflammatory phenotype exhibit one or more of the following properties upon contact with one or more agents: a) (ii) reduced expression and/or secretion of cluster of differentiation 80(CD80), CD86, MHCII, MHCI, interleukin 1-beta (IL-1 beta), IL-6, CCL3, CCL4, CXCL10, CXCL9, GM-CSF and/or tumor necrosis factor alpha (TNF-alpha)