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Subsequent studies demonstrated that symbiotic bacteria can promote LN progression by disrupting intestinal permeability, amplifying systemic inflammation, and activating the immune system ( Figure 4 ) [155, 156]

These effects are believed to result from enhanced fatty acid oxidation and improved cellular energy balance, contributing to overall metabolic health optimization

These integrative omics-based approaches not only validate traditional ethnopharmacological knowledge but also facilitate target identification, drug repurposing, and biomarker discovery (Zhu et al., 2022)