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Conversely, numerous preclinical studies reported the beneficial effects and safety of using PGC-1 or PPAR agonists occurring in natural sources, such as polyphenols, terpenoids, and polyacetylenes [30,31,32]

Moreover, the present study demonstrated that treatment with L-carnitine significantly reduced the gene expression of Caspase-9 and significantly increased the gene expression of Bcl-2

[2] This phase may then be followed by seizures, slow heart rate, low blood pressure, loss of consciousness, and cardiac arrest