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A British Society for Hematology Guideline

doi: 10.1038/nrrheum.2017.10 71 RosserECOleinikaKTononSDoyleRBosmaACarterNAet al

A crucial shared mechanism is the inhibition of the NF-B pathway, achieved through suppression of IB phosphorylation and prevention of p65 nuclear translocation, thereby reducing the expression of anti-apoptotic proteins