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Neuron (2012) 76(1):7081

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The second peak, mediated at least in part by NOX1, NOX3 and mitochondrial enzymes, results in prolonged signaling through PI3K, NF-B, and AKT

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However, despite being estimated to have similar extinction coefficient compared to the first charge transfer absorption (Figure 3A inset), the C159S variant is observed to only fractionally reduce to 20% and the NADPH-FAD charge transfer absorption dominates the observation of initial events in the reductive half-reaction as a result of residual NADPH