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Both studies administered B12 i.m., one used methyl-B12 at a dose of 500 g three times per week for 2 weeks, 63 the other used cyano-B12, 1000 g daily for 2 weeks

Fox SH, Katzenschlager R, Lim S-Y, Ravina B, Seppi K, Coelho M, Poewe W, Rascol O, Goetz CG, Sampaio C (2011) The Movement Disorder Society evidence-based medicine review update: treatments for the motor symptoms of Parkinsons disease

Patients will often report severe loss of energy even when sleep has been adequate