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373 The pharmacological targeting of key molecules within this signaling pathway may provide new therapeutic avenues for combating immune aging and related diseases caused by HSC senescence

After EMT, some cells retain most of the characteristics of epithelial cells, but also acquire some of the properties of mesenchymal cells while some cells are completely transformed into mesenchymal cells

Amino acid availability is primarily conveyed to mTORC1 via the GATOR1/GATOR2-RAG signaling axis, 28,47 whereas growth factors and energy activate mTORC1 through the TSC-RHEB axis (Fig