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For example, severe neuroinflammation (brain fog) can dysregulate the autonomic nervous system, leading to worsened POTS symptoms (tachycardia), which in turn triggers mast cell degranulation (histamine release)

Synthesis declines 1%/year after age 20[2]

An update on reactive astrocytes in chronic pain

To orient the reader, Figure 2 schematizes the core oxidative-stress network, with compound-level cross-references in Appendix B: Supplementary Table 1