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Vitam Horm 119:241274 ( Elsevier ) Kuijpers TW, de Vries AC, van Leeuwen EM, Ermens AT, de Pont S, Smith DE, Wamelink MM, Mensenkamp AR, Nelen MR, Lango Allen H, Pals ST (2022) Megalobastic anemia, infantile leukemia, and immunodeficiency caused by a novel homozygous mutation in the DHFR gene

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[19] [20] Improved wellbeing: Patients with confirmed deficiency often report enhanced energy and cognitive function following appropriate replacement therapy