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In the IRI model, elevated expression of the E3 Ub-protein ligase HMG-CoA reductase degradation protein 1 (HRD1) increases ubiquitinated degradation of the -catenin degradation complex, stabilizes -catenin proteins, and thereby enhances Wnt / -catenin signaling[50]

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Additionally, when considering cognitive decline caused by aging, dietary intake of caffeine can protect the brain by regulating the Bax/Bcl2 ratio, caspase-3, and PARP-1 levels to reduce oxidative stress, and COX-2, NOS-2, TNF, and IL-1 to further reduce D-galactose-induced neuroinflammation and neurodegeneration (Ullah et al., 2015)

DN is characterized by the thickening of both tubular and glomerular basement membranes, the merging and loss of podocyte foot processes, as well as the proliferation of the mesangial matrix (Thomas et al., 2015

Goodman, J