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Furthermore, compound 16 is degraded considerably more slowly in membrane preparations than Ang IV and stimulates proliferation of mouse neural stem cells at low concentrations, supporting a role of IRAP in neurogenesis (Axn et al., 2007)

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Disruptions in the NVU, leading to BBB dysfunction and reduced CBF, are early events in various neurodegenerative diseases, including AD, PD, and ALS [85]

BPC 157 increased nitric oxide production and activated the eNOS phosphorylation as reported in our previous study 6