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This situation can lead to tissue death and requires immediate emergency surgery

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In AR-positive cells such as LNCaP, MYC also upregulates ASCT2 expression and enhances glutamine uptake in an androgen-responsive manner (39)

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On the contrary, activation of the TSS pathway under physiological cystine supplement is achieved under DMF treatment through enhanced CBS expression and cystine uptake to protect against ferroptosis in SCD erythroblasts