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and synthetic compounds (chlormethiazole and YH-439 137,284 ) can prevent alcohol-induced oxidative stress and the formation of various adducts, including AA adducts 137 and AA-MAA adducts 53,285 , although the preventive effects of all these dietary compounds on AGE-associated adduct formation have not been specifically evaluated

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Similarly, QUE enhanced the killing effect of DOX on P388 leukemia cells by inhibiting the expression of NF-B, p65, and Bcl-2 but by activating Bax and Caspase-3 (52)

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For example, studies have identified genes such as brain-derived neurotrophic factor (BDNF) and the serotonin transporter gene (SLC6A4) as being closely associated with depression susceptibility [292,293,294]