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There are a few rules to follow here, though, if it is to be successful

Others might theoretically conflict with metabolic pathways already being modulated

[83] In another experiment using a rat model of Alzheimer's disease, it was demonstrated that systemic administration of hypothalamic proline-rich peptide (PRP)-1 offers neuroprotective effects and can prevent neurodegeneration in hippocampus amyloid-beta 2535

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This property makes them particularly amenable to surface modifications, such as coating with polymers or targeting ligands, to improve drug loading capacity