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Based on CD4 + T cells and monocytes from a multi-ethnic cohort of 461 healthy individuals, susceptibility alleles for MS, rheumatoid arthritis, type 1 diabetes, and PD were found to be overrepresented in CD4 + T cells, while disease- and trait-associated cis-eQTLs associated with AD and PD were primarily overrepresented in monocytes (87)

The laboratory measurement of S-adenosylmethionine and S-adenosylhomocysteine in plasma plays an increasing role in studies of pathogenesis of elevated homocysteine as well as the differential diagnosis of hypermethioninaemia due to deficiencies of methionine adenosyltransferase, glycine methyltransferase or S-adenosylhomocysteine hydrolase

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