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Carotenoids (including lycopene and -carotene), phenolic acids, flavonoids, vitamins C and E, and glycoalkaloids are responsible for the fruits anti-inflammatory, anti-cancer, and antioxidant qualities ( Figure 1 )

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There are no other prevalence studies of Dercum disease although the angiolipomatosis type is considered rare and the obesity- or lipedema-associated types are likely common, but these individuals are better described with what they have, angiolipomas, obesity, or lipedema respectively, with metabolic disease rather than lumping them all together as Dercum disease simply due to the presence of pain in the tissue

Furthermore, EGCG decreased both the expression and secretion levels of pro-inflammatory cytokine genes, including TNF-, IL-1, and IL-6

It promotes NRF2 ubiquitination through the Keap1/NRF2/ARE signaling pathway, induces ROS accumulation, and inhibits the phosphorylation of AktSer473 and mTORSer2448