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Finally, intrinsic and extrinsic pathways can activate the common effector caspases (e.g., 3 or 7) to trigger apoptosis [77]

This is based on the considerations that UV irradiation has been used as an ROS stress model because the major damage mechanism of UVB is the increase in ROS production and that astrocytes in optic nerve head get direct UV irradiation

Genetic variation in gpbar1 predisposes to quantitative changes in colonic transit and bile acid excretion

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