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Our results demonstrated that LPS- exposure induced the inflammatory response, including cytokine expression (IL6, IL-1, TNF) in macrophages, along with Trp-catabolic enzymes IDO1 and associated catabolites Kyn levels in both THP1 and primary KCs

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This scoring system allowed for semi-quantitative evaluation of cartilage integrity based on macroscopic features such as softening, fibrillation, erosion, ulceration, and complete cartilage loss [1]

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