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Tryptophan depletion sensitizes the AHR pathway by increasing AHR expression and GCN2/LAT1-mediated kynurenine uptake, and potentiates induction of regulatory T lymphocytes

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These pathways primarily involve organelle damage, ion channel abnormalities, cytoskeletal structure and axon degeneration, neuroinflammation, cellular dysfunction, and central nervous system (CNS) dysfunction