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Conclusion : Inhibiting hepatic Wnt signaling results in lower levels of glutamine and mTOR activity, prompting an increase in autophagy that clears the accumulated porphyrin-protein complexes and helps alleviate porphyria (Figure 1)

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HIF-1 plays a key role in treatment resistance, particularly in radiotherapy, by activating antioxidant systems that mitigate ROS-induced DNA damage