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Additionally, participants consumed approximately 23 times the recommended daily intake over a period of 10 years

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This is not a reason to dismiss the studies, but it is a reason to read them critically: several trials were funded or conducted by companies with a commercial interest in the result, sample sizes are typically in the dozens, follow-up rarely extends beyond a few months, and publication bias toward positive cosmetic outcomes is a recognized concern

Studies with unclear experimental methods, insufficient sample sizes, or unvalidated outcome measures were excluded for quality filtering