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Taken together, these findings suggest that Mn enhances the toxicity of arsenic to endothelial cells, exacerbating oxidative stress and inflammatory responses, which may have potential implications for cardiovascular diseases

Supplementary Table 1: Canonical phosphorylation sites in RyR2

Inflammatory and hormonal markers are assessed to understand how systemic inflammation, stress response, and hormonal balance may be influencing tissue repair, skin aging, or recovery processes