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136,137 This compensatory activation of AKT limits the efficacy of mTORC1-targeted therapies and underscores the rationale for using dual PI3K/mTOR or mTORC1/mTORC2 inhibitors to prevent feedback-driven survival signaling

[DOI] [PubMed] [Google Scholar] [174].Breitbach K, Rottner K, Klocke S, et al

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