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In humans, meta-analyses of intervention studies using carnitine have documented reductions in body weight and fat mass in overweight and obese adults [4] , as well as markers of systemic inflammation , including C-reactive protein (CRP), tumor necrosis factor alpha (TNF-), and interleukin-6 (IL-6) [5,6]

This small molecule exists mainly in two forms: reduced (GSH) and oxidized (GSSG)

The most common of them include Cu 2+ /Zn 2+ superoxide dismutase 1 ( SOD1 ), TAR DNA-binding protein 43 ( TARDBP) , fused in Sarcom a ( FUS ) , and chromosome 9 open reading frame 72 ( C9orf72) genes, involved in protein homeostasis and RNA metabolism [72,73,74,75]

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This study suggests a link between GSH metabolism and the epigenetic regulation of VD metabolism gene