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Description

2008 Feb;102(2):248-55

40 , W452W457 (2012)

Copenhagen (Virtual), DK

In addition to dopaminergic neuronal loss in the SN and the onset of motor symptoms in PD, these changes cause microgliosis, mitochondrial failure, oxidative stress, and inflammation

A decrease in bioenergetic efficiency is double-faced: it may be beneficial to cellular function through the reduction of reactive oxidative species production and the balancing of nutrient availability [272], but it may also contribute to increasing mitochondrial dysfunction and toxicity [273], which couldaccount for a significant proportion of adverse effects of prescription drugs [26]