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Loukas, A., Bethony, J., Brooker, S

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Oxidative imbalance, which results in oxidative stress, is associated with the development of numerous diseases, including cardiovascular diseases, e.g., myocardial ischemia, varicose vein, thrombosis, stroke (ischemia-reperfusion damage), but also diabetes, neurodegenerative diseases, can- cer, and many others [ 4 7 ]

Accordingly, neurodegenerative changes are present in other areas of the nervous system, such as the peripheral, autonomic, and enteric nervous systems [15, 16], and -synuclein aggregates may be detected outside the nervous system, including in the digestive tract, skeletal muscles, heart, adrenal glands, kidneys, urogenital system, and skin [22]

This feeling can indicate more than just a busy schedule or normal tiredness