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In the present study, hAAT OX treatment led to increased expression of iNOS and catalase, as well as increased activation of the Nrf2/ARE pathway, and caused elevated levels of ROS production in macrophage cultures

Therefore, it remains unclear if SAM constitutes the signal or driver for Cys4p oligomerisation

Genes Cells 25(6):364374

ZhouQQVerneMLFieldsJZLefanteJJBasraSSalamehHet al

By analogy with findings in other cell types, MAMs may potentiate the activity of Ca 2+ -dependent enzymes in the TCA cycle by regulating Ca 2+ transfer between the ER and mitochondria, thereby potentially enhancing mitochondrial OXPHOS efficiency and ATP production