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Author contributions D-DW, S-MH, PZ, and Q-LW conceived and designed the study

[25] Osmotic laxatives: Osmotic is a derivative of the word osmosis, meaning water as the name suggests, osmotic laxatives, often given in oral form, encourage the intestinal wall to hold in more water via osmosis, which stretches these muscles and helps trigger a defecation reflex

(2), what is the optimal treatment regimen since various treatment regimenswere used in the reported studies

Further research remains warranted to address unanswered questions, such as whether DN results from global metabolic reprogramming of the PNS and how energy transfer or toxic byproducts between nerve cells contribute to the disease

2026 Mar 1;21