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While often considered bad actors, ROS and RNS also play physiological roles in mammals and are produced by dedicated enzymes that use NADPH as the reductant: NADPH oxidase (NOX) or nitric oxide synthase (NOS) 7

Beebe, PhD, is studying the vitreous in collaboration with Purdue biomedical engineer Alyssa Panitch, PhD, who studies degradation or liquefaction of cartilage

When mitochondrial damage occurs, ROS production is significantly higher compared to normal physiological levels