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Bulk RNA-seq data of skin lesions from diabetic patients and healthy subjects were also obtained from the GEO database (GSE154556)

Regarding the mechanisms of crossing the nasopharyngeal barrier, a combination of transcellular and paracellular pathways seems possible if meningococci using the transcellular pathway induce a sufficient level of inflammation to alter epithelial permeability, allowing other meningococci to follow the paracellular pathway

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