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Cytoplasmic protein aggregates, a pathological feature of ALS, disrupt key cellular degradation mechanisms, including both the ubiquitin-proteasome system and autophagy pathways, resulting in catastrophic failure of protein homeostasis

The logistical advantage of this stack is that 5-Amino-1MQ doesnt require cold-chain handling, reducing storage complexity when running concurrent protocols

Upregulation of AKT promoted the expression of Pirin and subsequent activation of nuclear factor erythroid 2related factor 2 (Nrf2) and the NF-B signaling cascade, protecting cells from OS effects on viability [53]

It is important to note some limitations of our study

platensis, is commonly used in a global scale