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Advances 81, 108564

doi: 10.1136/ard-2022-223568 147

The use of antioxidants such as glutathione (GSH) during chemotherapy or radiation therapy is controversial and probably not recommended [6]

Indeed, the decrease in PDC activity observed in our study was paralleled by a reduction in muscle lactate content and resulted in an accumulation of muscle glycogen overnight, conditions which are both consistent with the premise that glycolytic flux, and therefore carbohydrate oxidation, was inhibited