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Treatment of 3 T3L1 cells with 0.1 to 10 mol of ellagic acid or 30 mol of curcumin over a span of 2 to 3 days led to a substantial decrease in the mRNA and protein expression of key adipogenesis players, namely PPAR, C/EBP- , SREBP-1c, and ACC (67, 84)

After 30 minutes of vigorous intensity exercise, skeletal muscle lactate content was 44% lower, and pyruvate dehydrogenase activity was 38% greater signaling better maintenance of the acetyl-CoA/CoA ratio, and therefore less lactate accumulation and decreased reliance on anaerobic metabolism (31)

9.7 Gut Microbiota and Uremic Toxins and CVD Uremic toxicity is a big influencer of CVD risk related to CKD