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Studies involving cell-free systems and cell cultures demonstrate that the complete or partial substitution of cytidines with 5-methylcytidines stimulates target protein expression (Table 2)

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Based upon the results of the studies, we found that if 50 percent or more of HOPDs had billed these services with the cardiology revenue code (048X) and cardiology cost center (03140), the geometric mean cost for these codes would have increased and would have resulted in a revised APC assignment from APC 5571 (Level 1 Imaging with Contrast) to APC 5572 (Level 2 Imaging with Contrast)