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10.1002/j.1875-9114.2012.01024.x 25 HolbrookA

OR trafficking Once internalized, the OR can follow different routes: sequestration into endosomes, recycling back to the cell surface or targeting to degradation

126 In a randomized controlled trial, 40 patients with tinnitus (17 of whom also had vitamin B12 deficiency with levels below 250 pg/mL) were treated with weekly intramuscular injections providing 2,500 mcg vitamin B12 or saline (placebo) for six weeks