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Xin-Hui Wang, [email protected] These authors have contributed equally to this work Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Lang E, Lang F

These pro-inflammatory cytokines activate neutrophils, which release myeloperoxidase and catalase, giving way to an oxidative burst with implications on local tissue damage and initiating ECs junctional disassembly [118,119,120]

What exactly causes vitiligo is difficult to pinpoint, although it is thought to be a combination of a number of factors, including: Autoimmune Reaction: Vitiligo is generally regarded as an autoimmune disease whereby the body begins to attack its own melanocytes (the cells responsible for producing melanin) and either destroys the cells or leaves them damaged and nonfunctional

It was developed by Metabolic Pharmaceuticals, an Australian biopharmaceutical company, in the late 1990s as a potential therapeutic for obesity and metabolic disorders