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Off-Label Dosing Protocols Used in Clinical Practice Because no clinical trials have established human dosing, all dosing information below reflects empirical protocols used by peptide-prescribing clinicians

While some benefits have been observed in several studies for the various diseases and conditions discussed here, the side effects associated with anti-VEGF or anti-VEGFR-2 therapies can be severe and include heightened risk of arterial thromboembolic events, hypothyroidism, wound healing complications, GI perforations, neutropenia and hematological effects and increased risks for other cardiac adverse events (245, 247249)

The loading doses in the UK are 6 injections of 1mg/ml hydroxcobalamin ovef a 2 week period IM

The medicine is also advised to be used with caution in elderly patients (aged above 65 years) after consulting the doctor

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