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This is especially important during endurance events as you can easily become fatigued when your body, especially muscles, does not have enough oxygen

As this article is a review and does not report any new data collected by the authors, separate Institutional Review Board (IRB) or Ethics Committee approval was not sought or required for its preparation

Due to institutional and privacy restrictions, these data are not publicly accessible via a repository

The classic example is a patient who has an allergy to an inactive ingredient in an approved drug and needs a version of the drug without that allergen, says Zettler